The Biomedical and Analytical Center (BAC), housed at the Chemistry Department of the University of Ioannina, since its establishment in 2015 has gained a great expertise in multiple disciplines.Its research encompasses a wide variety of projects including targeted and untargeted metabolomic analysis of plants, products of animal origin, and different biological matrices for different compound categories including phytochemicals, drugs, pollutants, pesticides, etc., as well as bioavailability, pharmacokinetics, and bioequivalence studies. It houses state-of-the-art equipment including a unique hybrid GC/UHPLC-QToF mass spectrometry system (Waters Xevo G2-XS), a triple quadruple UHPLC-MS/MS system (Bruker EVOQ Elite), preparative and analytical HPLC systems, UV/Vis and fluorescence spectrometry systems, platform for plant extracts and essential oil production using SFE (supercritical fluid extraction), microwave organic synthesis platform, protein expression/purification platform, in silico-screening platform. Furthermore, the lab has access to cell cultures and cell-based screening platforms, HS-SPME/GC-MS, high resolution NMR and Orbitrap MS systems.UOI has been a key partner on the BEST project “Addressing joint Agro- and Aqua- Biodiversity pressures Enhancing SuSTainable Rural Development -BEST” INTERREG V/A GREECE-ITALY 2014-2020. UOI is a founding member of the national “Infrastructure of Microbiome Applications in Food Systems (FOODBIOMES)“ in Greece

Agriculture
Biochemistry
Diagnosis (microarray and biosensing devices for early / precise detection of diseases)
Metabolism
Organic Chemistry
Pharmacology
Plant Biotechnology
Plant Protection
Plant Sciences
Plant Selection
Selection using molecular markers

Metabolites play a key role in all organisms by regulating, balancing, adapting to habitats, physical and climatic factors, and protecting against pathogens and predators.Metabolites are the result of both biological and environmental factors, and as such provide great potential to bridge knowledge of genotype and phenotype.These metabolites also referred to as biological markers or biomarkers, can be transferred from one organism to another through the food chain, as well as to any of their products.Biomarkers have been successfully used in several research areas, including biodiversity studies, environmental quality monitoring of protected areas, and health assessment of species at risk.Up to now their discovery is mainly based on genetic-based approaches, but recently, the application of untargeted high-resolution mass spectrometry (HRMS)-based metabolomics for biomarker discovery is constantly gaining ground.The HRMS screening has already shown its potency to generate efficiently the chemical profile of any natural product but combining it with novel bioinformatic approaches can greatly assist the identification of relevant biomarkers.The application of chemometric statistics on the previously obtained chemical profile can allow us to draw conclusions and make connections between data, leading to the creation of new knowledge.Mass spectrometry (MS) and multivariate data analysis (MVA) have been widely used to show the differences between samples and to identify biomarkers

targeted and untargeted metabolomic analysis of plant extracts, pesticide and mycotoxin screening, forensic toxicology analysis, natural products analysis, exploitation of different genotypes, pharmaceutical and aromatic plants, plant-based phytochemicals metabolites, biodiversity charting and conservation, biomarkers, mass spectrometry

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